{"product_id":"shop-same-200-mg-metabolic-maintenance","title":"SAMe 200 mg","description":"\u003cp style=\"text-align: justify; margin: 0cm 0cm 12.0pt 0cm;\"\u003eNaturally occurring in our bodies, SAMe is one versatile molecule. It is used as a critical methyl donor throughout the body aiding in cellular protection. SAMe crosses the blood-brain barrier and contributes to the formation of dopamine, serotonin and norepinephrine, supporting balanced mood. It has also been shown to promote healthy joint function and liver health. Though versatile and effective, the molecule can be unstable. Our form combines SAMe with calcium making it less sensitive to humidity and temperature. This means you can get the benefits of SAMe without ingesting the chemicals involved in a coated tablet or hassling with refrigeration. To promote maximum efficacy, we provide our clean version of SAMe in acid resistant capsules for release in the intestine.*\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromotes positive mood*\u003c\/li\u003e\n\u003cli\u003eImproves brain function*\u003c\/li\u003e\n\u003cli\u003eSupports healthy joints*\u003c\/li\u003e\n\u003cli\u003eStable, acid-resistant formulation\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: justify; margin: 0cm 0cm 12.0pt 0cm;\"\u003e\u003cstrong\u003eWhat is SAMe?\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSAMe (pronounced like the name “Sammy”), or S-Adenosyl-L-methionine, is a metabolite of the amino acid L-methionine and can be found in all cells of the body. SAMe is a substrate crucial to three central metabolic pathways: methylation; transsulfuration; and transaminopropylation. The transsulfuration pathway ultimately leads to the synthesis of glutathione, a cellular antioxidant involved in numerous biological functions, including, importantly, detoxification in the liver. SAMe also plays a crucial biochemical role as a methyl donor in the synthesis of neurotransmitters, nucleic acids, phospholipids, and proteins. \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eThrough these pathways, SAMe is also involved in the synthesis of proteoglycans for cartilage, myelination, and synthesis of carnitine, coenzyme Q10, and creatinine, the formation of cysteine, other endogenous anti-inflammatory, neurotrophic, and antioxidant molecules, as well as the synthesis, repair, and recombination of DNA.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSAMe has been shown to exert anti-inflammatory activity in patients affected with osteoarthritis. Finally, other studies demonstrated its activity in supporting liver health in those with alcoholic hepatitis and cirrhosis.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cstrong\u003eHow does SAMe Work?\u003c\/strong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSince its discovery, SAMe has been extensively studied for its ability to promote a positive mood and emotional balance, but the precise mechanism of this effect is still somewhat unclear. \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIt is known, however, that SAMe does cross the blood-brain barrier, and when distributed to the brain, it stimulates the activity of dopaminergic and serotonergic pathways, probably through its involvement in transmethylation processes. We also know that SAMe-dependent methylation reactions are required for our cells to make all of the positivity and alertness-associated neurotransmitters: dopamine, serotonin, epinephrine, and norepinephrine. The networks of neurons that respond to the messages sent by these neurotransmitters are involved in the regulation of cognitive processes such as emotion, and certain types of memory. \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn the midst of mood-related research, scientists noted that SAMe treatments also lead to improved arthritis symptoms—an unintended, positive side effect. Many years and numerous clinical studies later, we now know that SAMe can be about as effective as standard anti-inflammatory drugs in easing the symptoms of osteoarthritis. Because of these findings, for the last 20 years, SAMe has been touted in the US as a dietary supplement that promotes joint health, mobility, and joint comfort. In a similar manner to a glucosamine and chondroitin regimen, the response to SAMe is very long-lasting and suggests that this nutrient has a deeper impact on osteoarthritis than simply relieving symptoms. It is likely that SAMe also has a protective effect against damage to cartilage.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn all cells, SAMe is involved in the biosynthesis of phospholipids which play several important roles within the cell membrane. These roles include regulation of cellular enzymatic and bioelectrical activity and the maintenance of membrane fluidity. Membrane fluidity, specifically in brain cells, has been linked with the efficacy of binding sites for neurotransmitters like dopamine and stress signals. This may also explain, at least in part, the effect of SAMe on boosting hepatic (liver) function, as chronic liver disease has been shown to cause changes in cell membrane composition and enzymatic activity of hepatocytes. Glutathione is also a key player in detoxification within the liver, and SAMe supports the transsulfuration pathway that leads to glutathione production, preventing depletion of glutathione stores, normalizing mitochondrial enzyme activity, and preventing the production of acetaldehyde and deposition of fat in the liver.\u003c\/p\u003e\n\u003cp style=\"text-align: justify; margin: 0cm 0cm 12.0pt 0cm;\"\u003e\u003cstrong\u003eWhat is the Suggested Use for SAMe?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"text-align: justify;\"\u003e\n\u003cstrong\u003eMood and brain health\u003c\/strong\u003e. SAMe-dependent methylation reactions are vital for the synthesis of neurotransmitters: dopamine, serotonin, epinephrine, and norepinephrine. SAMe is also needed for phosphatidylcholine production which is vital for cell membrane fluidity and central nervous system function. SAMe deficiency has been reported in patients with inherited defects in folate and methionine metabolism (such as MTHFR mutations) as well as in common diseases such as depressive disorders, Alzheimer's Dementia, Parkinson's Disease, and HIV. Supplementation can help to combat these deficiencies.\u003c\/li\u003e\n\u003cli style=\"text-align: justify;\"\u003e\n\u003cstrong\u003eJoint health\u003c\/strong\u003e. SAMe has been shown to promote joint comfort by increasing the production of proteoglycans and reducing inflammatory mediators, among other effects.\u003c\/li\u003e\n\u003cli style=\"text-align: justify;\"\u003e\n\u003cstrong\u003eLiver health\u003c\/strong\u003e. SAMe contributes to the fluidity of liver cell lipid membranes, plays a role in detoxification pathways, and increases hepatic glutathione levels for liver health.\u003c\/li\u003e\n\u003cli style=\"text-align: justify;\"\u003eOur capsules are acid-resistant to protect SAMe from the low pH of the stomach and deliver it to the small intestine where it is absorbed. Metabolic Maintenance uses SAMe stabilized with calcium made by Gnosis-Bio in Italy. It does not require refrigeration or coatings.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"text-align: justify; margin: 0cm 0cm 12.0pt 0cm;\"\u003e\u003cstrong\u003eSource Materials\u003c\/strong\u003e: SAMe and L-leucine are made by fermentation. Calcium and magnesium are mined minerals. Cellulose for capsules is derived from softwood tree pulp. Gellan gum for acid resistant capsules is made by fermentation with Pseudomonas elodea. All ingredients are vegan and non-GMO.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cstrong\u003eAllergens\u003c\/strong\u003e: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0400\/2273\/files\/SAMe200mg_MetabolicMaintenance_sf-min_99ae9bf7-0c22-425e-815f-6f0dc611136b_480x480.png?v=1696940081\" alt=\"SAMe 200 mg (Metabolic Maintenance)\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: justify; margin: 0cm 0cm 12.0pt 0cm;\"\u003e\u003cstrong\u003eRecommendations\u003c\/strong\u003e: One to two (1-2) capsules daily, between meals, or as directed by a healthcare professional.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement. If you suffer from bipolar (manic) depression, do not use this product.  \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e-See \u003c\/span\u003e\u003ca title=\"Easy, No Hassle Returns\" href=\"https:\/\/www.shop.dralexrinehart.com\/pages\/return-policy\" target=\"_blank\"\u003eSatisfaction\u003cspan\u003e \u003c\/span\u003ePolicy\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e-Other \u003ca title=\"Metabolic Maintenance\" href=\"https:\/\/www.shop.dralexrinehart.com\/collections\/metabolic-maintenance\"\u003e\u003cstrong\u003eMetabolic Maintenance Products\u003c\/strong\u003e\u003c\/a\u003e \u003c\/p\u003e\n\u003cp\u003eSKU \/ UPC Barcode: 838287001546\u003c\/p\u003e\n\u003cp style=\"text-align: justify; margin: 0cm 0cm 12.0pt 0cm;\"\u003e\u003cspan\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/span\u003e\u003c\/p\u003e","brand":"Metabolic Maintenance","offers":[{"title":"60ct","offer_id":40279041146965,"sku":"MM-00154","price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0400\/2273\/files\/SAMe200mg_MetabolicMaintenance_-min_1d4c58d4-26fc-413c-89ca-0e1d349257c4.png?v=1696940139","url":"https:\/\/www.shop.dralexrinehart.com\/products\/shop-same-200-mg-metabolic-maintenance","provider":"DrAlexRinehart.com","version":"1.0","type":"link"}