SAMe

SAMe (as S-adenosyl-L-methionine) is a naturally occurring metabolite found in the human body and in plant and animal foods. It is the most active of all methyl donors and has been compared to adenosine triphosphate (ATP) in its importance for the body. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors vitamin B12 and folate.

SAMe is involved in the synthesis of neurotransmitters, the hormone melatonin, phospholipids, and polyamines, which control cellular growth. It is also the source of methyl groups inside the nucleus for DNA methylation, which controls gene expression and the masking of genetic damage.*

S-adenosyl-L-methionine (SAMe) is an internally produced compound found in every cell of the human body that is involved in more than 100 biochemical reactions. SAMe is naturally synthesized in humans from the energy molecule adenosine triphosphate (ATP) and the amino acid methionine in the presence of adequate levels of folate and vitamin B12. SAMe is highly concentrated in the liver, adrenal glands, and pineal gland, and it is uniformly distributed throughout the brain.

SAMe is integral to cellular energy metabolism and homeostasis, as it serves as the body’s principal methyl donor, a molecule that is added to another compound (e.g., DNA, protein) to support that compound’s proper function in the body.* This process is called methylation, a continuous cycle that is involved in the synthesis and healthy functioning of neurotransmitters, phospholipids, proteins, hormones, DNA and RNA, polyamines, and glutathione (the body’s master antioxidant).* Proper functioning of these substances are critical for optimal nervous, cardiovascular, and immune system activity, hormone balance, detoxification, genetic expression and modification, and energy production.*

Designs for Health’s SAMe capsules provide 200 mg of stabilized S-adenosyl-L-methionine (SAMe) per capsule to support biochemical pathways crucial to healthy cellular metabolism that require a steady source of SAMe.* These capsules also provide vitamins B6, B12, and folate, which are nutrient cofactors required for the proper and efficient function of SAMe.

The natural aging process, dietary deficiency of methionine, folate, vitamins B12 and B6 (i.e., poor protein intake, vegan/vegetarian diets), inflammatory states, emotional/physical stressors, and genetic variants all contribute to suboptimal levels of SAMe and, thus, may increase demand for this essential compound.

Benefits*

• Helps support brain function and memory
• May encourage a positive mental outlook and balanced mood
• Supports healthy liver function
• Helps support antioxidant status
• May help reduce oxidative stress
• May help support a healthy inflammatory response
• Helps maintain cell membrane integrity and fluidity

Highlights

• 200 mg of patented, stabilized SAMe per capsule
• Uses the methylated forms of folate and vitamin B12 for enhanced bioavailability and methylation support*
• Unique encapsulation technology designed to withstand the acidic environment within the stomach, allowing for intact absorption into the small intestine for superior absorption and bioavailability*
• Innovative encapsulation technology allows for the inclusion of cofactors 5-methyltetrahydrofolate (5-MTHF [folate]) and methylcobalamin (vitamin B12) in clinically relevant doses*

Supplement Facts

Recommended Use: Take 1 capsule per day, preferably on an empty stomach, or as directed by your health-care practitioner. 

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SKU / UPC Barcode: 879452003774

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.